Therapeutic Potential of Sodium Channel Blockers as a Targeted Therapy Approach in <i>KCNA1</i>-Associated Episodic Ataxia and a Comprehensive Review of the Literature.

Lauxmann, Stephan; Sonnenberg, Lukas; Koch, Nils A; Bosselmann, Christian; Winter, Natalie; Schwarz, Niklas; Wuttke, Thomas V; Hedrich, Ulrike B S; Liu, Yuanyuan; Lerche, Holger; Benda, Jan; Kegele, Josua

Therapeutic Potential of Sodium Channel Blockers as a Targeted Therapy Approach in KCNA1-Associated Episodic Ataxia and a Comprehensive Review of the Literature.

Lauxmann, Stephan; Sonnenberg, Lukas; Koch, Nils A; Bosselmann, Christian; Winter, Natalie; Schwarz, Niklas; Wuttke, Thomas V; Hedrich, Ulrike B S; Liu, Yuanyuan; Lerche, Holger; Benda, Jan; Kegele, Josua.

Afiliação

Lauxmann S; Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Sonnenberg L; Institute of Neurobiology, University of Tübingen, Tübingen, Germany.
Koch NA; Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Bosselmann C; Institute of Neurobiology, University of Tübingen, Tübingen, Germany.
Winter N; Bernstein Center for Computational Neuroscience Tübingen, Tübingen, Germany.
Schwarz N; Institute of Neurobiology, University of Tübingen, Tübingen, Germany.
Wuttke TV; Bernstein Center for Computational Neuroscience Tübingen, Tübingen, Germany.
Hedrich UBS; Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Liu Y; Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Lerche H; Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Benda J; Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Kegele J; Department of Neurosurgery, University of Tübingen, Tübingen, Germany.

Front Neurol ; 12: 703970, 2021.

Article em En | MEDLINE | ID: mdl-34566847

Palavras-chave

KCNA1; KV1.1; conduction-based model; episodic ataxia; precision medicine; riluzole; sodium channel blockers; voltage-gated potassium channels

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article