Voatriafricanines A and B, Trimeric Vobasine-Aspidosperma-Aspidosperma Alkaloids from Voacanga africana.
J Nat Prod
; 84(10): 2755-2761, 2021 10 22.
Article
em En
| MEDLINE
| ID: mdl-34569237
ABSTRACT
Voatriafricanines A and B (1 and 2), the first examples of vobasine-aspidosperma-aspidosperma monoterpene trisindole alkaloids, were isolated from the stem barks of Voacanga africana, guided by a molecular networking strategy. Their structures, including absolute configurations, were elucidated by spectroscopic methods and ECD calculations. Compounds 1 and 2 possess intramolecular hydrogen bonding, sufficiently robust to transfer homonuclear and heteronuclear magnetizations. Compound 1 exhibited potent antimycobacterial activity with no discernible cytotoxic activity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Alcaloides Indólicos
/
Voacanga
/
Antibacterianos
País como assunto:
Africa
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article