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A Combined TLR7/TLR9/GATA3 Score Can Predict Prognosis in Biliary Tract Cancer.
Branchi, Vittorio; Esser, Laura; Boden, Corinna; Jafari, Azin; Henn, Jonas; Lingohr, Philipp; Gonzalez-Carmona, Maria A; Schmitz, Marc; Weismüller, Tobias J; Strassburg, Christian P; Manekeller, Steffen; Kristiansen, Glen; Kalff, Jörg C; Matthaei, Hanno; Toma, Marieta I.
Afiliação
  • Branchi V; Department of General, Visceral, Thoracic and Vascular Surgery, University Hospital Bonn, 53127 Bonn, Germany.
  • Esser L; Institute of Pathology, University Hospital Bonn, 53127 Bonn, Germany.
  • Boden C; Department of General, Visceral, Thoracic and Vascular Surgery, University Hospital Bonn, 53127 Bonn, Germany.
  • Jafari A; Department of General, Visceral, Thoracic and Vascular Surgery, University Hospital Bonn, 53127 Bonn, Germany.
  • Henn J; Department of General, Visceral, Thoracic and Vascular Surgery, University Hospital Bonn, 53127 Bonn, Germany.
  • Lingohr P; Department of General, Visceral, Thoracic and Vascular Surgery, University Hospital Bonn, 53127 Bonn, Germany.
  • Gonzalez-Carmona MA; Department of Internal Medicine I, University Hospital Bonn, 53127 Bonn, Germany.
  • Schmitz M; Institute of Immunology, Faculty of Medicine Carl Gustav Carus, TU Dresden, 01307 Dresden, Germany.
  • Weismüller TJ; National Center for Tumor Diseases (NCT), Partner Site Dresden, 01307 Dresden, Germany.
  • Strassburg CP; German Cancer Consortium (DKTK), Partner Site Dresden, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  • Manekeller S; Department of Internal Medicine I, University Hospital Bonn, 53127 Bonn, Germany.
  • Kristiansen G; Department of Internal Medicine I, University Hospital Bonn, 53127 Bonn, Germany.
  • Kalff JC; Department of General, Visceral, Thoracic and Vascular Surgery, University Hospital Bonn, 53127 Bonn, Germany.
  • Matthaei H; Institute of Pathology, University Hospital Bonn, 53127 Bonn, Germany.
  • Toma MI; Department of General, Visceral, Thoracic and Vascular Surgery, University Hospital Bonn, 53127 Bonn, Germany.
Diagnostics (Basel) ; 11(9)2021 Sep 01.
Article em En | MEDLINE | ID: mdl-34573939
ABSTRACT
Biliary tract cancer (BTC) refers to a heterogenous group of epithelial malignancies arising along the biliary tree. The highly aggressive nature combined with its silent presentation contribute to the dismal prognosis of this tumor. Tumor-infiltrating immune cells (TIICs) are frequently present in BTC and there is growing evidence regarding their role as therapeutic targets. In this study, we analyzed the immune cell infiltration in BTC and developed a promising immune signature score to predict prognosis in BTC. Immunohistochemistry (IHC) was carried out on tissue microarray sections from 45 patients with resectable cholangiocarcinoma for the detection of 6-sulfoLacNAc+ monocytes (slanMo), BDCA-2+ plasmacytoid dendritic cells (pDC), CD8+ or CD4+T-lymphocytes, CD103+ cells, GATA3+ cells, Toll-like receptor (TLR) 3, 7 and 9-expressing cells as well as programmed cell death protein 1 and programmed cell death ligand 1 positive cells. Data from the IHC staining were analyzed and correlated with clinicopathological and survival data. High expression of TLR7, TLR9, and GATA3 was associated with improved overall survival (OS, Log-rank p < 0.05). In addition, TLR9 was associated with better disease-free survival (Log-rank p < 0.05). In the multivariate Cox proportional-hazards model for OS, the TLR/TLR9/GATA3 score was found to be an independent prognostic factor for OS ("Score 2" vs. "Score 0" HR 11.17 95% CI 2.27-54.95, p < 0.01).
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article