Scalable Asymmetric Synthesis of MK-8998, a T-Type Calcium Channel Antagonist.
J Org Chem
; 87(4): 2120-2128, 2022 02 18.
Article
em En
| MEDLINE
| ID: mdl-34582192
ABSTRACT
Two scalable and efficient synthetic routes for the synthesis of a T-type calcium channel antagonist MK-8998 were developed from a simple pyridine building block. The key step to set the stereochemistry relied on either chiral rhodium catalyst-mediated asymmetric hydrogenation of an enamide or transamination of an arylketone that provided the corresponding product in high enantioselectivity and high yield.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ródio
/
Bloqueadores dos Canais de Cálcio
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article