Cognate recognition of microbial antigens defines constricted CD4+ T cell receptor repertoires in the inflamed colon.
Immunity
; 54(11): 2565-2577.e6, 2021 11 09.
Article
em En
| MEDLINE
| ID: mdl-34582747
ABSTRACT
Key aspects of intestinal T cells, including their antigen specificity and their selection by the microbiota and other intestinal antigens, as well as the contribution of individual T cell clones to regulatory and effector functions, remain unresolved. Here we tracked adoptively transferred T cell populations to specify the interrelation of T cell receptor repertoire and the gut antigenic environment. We show that dominant TCRα clonotypes were shared between interferon-γ- and interleukin-17-producing but not regulatory Foxp3+ T cells. Identical TCRα clonotypes accumulated in the colon of different individuals, whereas antibiotics or defined colonization correlated with the expansion of distinct expanded T cell clonotypes. Our results demonstrate key aspects of intestinal CD4+ T cell activation and suggest that few microbial species exert a dominant effect on the intestinal T cell repertoire during colitis. We speculate that dominant proinflammatory T cell clones might provide a therapeutic target in human inflammatory bowel disease.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores de Antígenos de Linfócitos T
/
Linfócitos T CD4-Positivos
/
Colite
/
Interações Hospedeiro-Patógeno
/
Microbioma Gastrointestinal
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article