Activation of Fibroblasts in Skin Cancer.
J Invest Dermatol
; 142(4): 1026-1031, 2022 04.
Article
em En
| MEDLINE
| ID: mdl-34600919
ABSTRACT
Fibroblasts have emerged as a dominant component of the tumor microenvironment, but despite the surging interest in the activation of fibroblasts and their role in cancer, they remain an elusive and complex cell type. In this perspective, we discuss the phenotypic plasticity of cancer-associated fibroblasts (CAFs) in melanoma and nonmelanoma skin cancer identified by genome-wide transcriptomic studies and focus on the molecular pathways underlying their activation. These studies reveal distinct fibroblast activation profiles depending on tumor type and stage. A better understanding of skin CAF heterogeneity in origin and function will guide novel therapeutic approaches targeting this cell type in clinical cancer care.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Fibroblastos Associados a Câncer
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article