Regional differences in prostacyclin formation by the kidney. Prostacyclin is a major prostaglandin of renal cortex.
Biochim Biophys Acta
; 529(1): 176-80, 1978 Apr 28.
Article
em En
| MEDLINE
| ID: mdl-346067
ABSTRACT
Microsomes prepared from rabbit renal cortex were found to synthesize substantial amounts of 6-ketoprostaglandin F1alpha from prostaglandin G2 or arachidonic acid during an incubation. In contrast, no 6-ketoprostaglandin F1alpha was formed by renal medullary microsomes which synthesize predominantly prostaglandin E2. Mass spectral confirmation of the structure of 6-ketoprostaglandin F1alpha from these incubations demonstrates the ability of the renal cortex to synthesize prostacyclin.
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Base de dados:
MEDLINE
Assunto principal:
Prostaglandinas
/
Epoprostenol
/
Córtex Renal
Limite:
Animals
Idioma:
En
Ano de publicação:
1978
Tipo de documento:
Article