Climbing Up and Down Binding Landscapes through Deep Mutational Scanning of Three Homologous Protein-Protein Complexes.

Heyne, Michael; Shirian, Jason; Cohen, Itay; Peleg, Yoav; Radisky, Evette S; Papo, Niv; Shifman, Julia M

Heyne, Michael; Shirian, Jason; Cohen, Itay; Peleg, Yoav; Radisky, Evette S; Papo, Niv; Shifman, Julia M.

Afiliação

Heyne M; Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, 9190401, Israel.
Shirian J; Avram and Stella Goldstein-Goren Department of Biotechnology Engineering and the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, 8410501, Israel.
Cohen I; Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, 9190401, Israel.
Peleg Y; Avram and Stella Goldstein-Goren Department of Biotechnology Engineering and the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, 8410501, Israel.
Radisky ES; Life Sciences Core Facilities (LSCF) Structural Proteomics Unit (SPU), Weizmann Institute of Science, Rehovot, 7610001, Israel.
Papo N; Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, United States.
Shifman JM; Avram and Stella Goldstein-Goren Department of Biotechnology Engineering and the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, 8410501, Israel.

J Am Chem Soc ; 143(41): 17261-17275, 2021 10 20.

Article em En | MEDLINE | ID: mdl-34609866

Assuntos

Mapeamento de Interação de Proteínas

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Mapeamento de Interação de Proteínas Tipo de estudo: Clinical_trials Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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