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Discovery of 1,8-naphthalidine derivatives as potent anti-hepatic fibrosis agents via repressing PI3K/AKT/Smad and JAK2/STAT3 pathways.
Lu, Zhen-Ning; Shan, Qi; Hu, Shang-Jiu; Zhao, Yue; Zhang, Guo-Ning; Zhu, Mei; Yu, Dong-Ke; Wang, Ju-Xian; He, Hong-Wei.
Afiliação
  • Lu ZN; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
  • Shan Q; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
  • Hu SJ; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
  • Zhao Y; Beijing Changping Technology Innodevelop Group, Beijing 102200, China.
  • Zhang GN; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
  • Zhu M; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
  • Yu DK; Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
  • Wang JX; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: wangjuxian@imb.cams.cn.
  • He HW; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: hehwei@imb.pumc.edu.cn.
Bioorg Med Chem ; 49: 116438, 2021 11 01.
Article em En | MEDLINE | ID: mdl-34610571
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Descoberta de Drogas / Cirrose Hepática / 1-Naftilamina Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Descoberta de Drogas / Cirrose Hepática / 1-Naftilamina Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article