Your browser doesn't support javascript.
loading
Targeted Therapy for BRAF Mutant Brain Tumors.
Rayi, Appaji; Alnahhas, Iyad; Ong, Shirley; Giglio, Pierre; Puduvalli, Vinay K.
Afiliação
  • Rayi A; Department of Neurology, Charleston Area Medical Center, Charleston, WV, USA.
  • Alnahhas I; Division of Neuro-Oncology, Department of Neurology, Thomas Jefferson University, Philadelphia, PA, USA.
  • Ong S; Division of Neuro-Oncology, Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Giglio P; Division of Neuro-Oncology, Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Puduvalli VK; Department of Neuro-Oncology, MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 431, Houston, TX, 77030, USA. vpuduval@mdanderson.org.
Curr Treat Options Oncol ; 22(11): 105, 2021 10 06.
Article em En | MEDLINE | ID: mdl-34613491
OPINION STATEMENT: Molecular heterogeneity has confounded attempts to target individual pathways in brain tumors. However, gliomas with BRAF mutations have been identified as being uniquely vulnerable to targeted therapies. Such mutations are predominantly seen in brain tumors of the adolescent and young adult population. Given that accurate and timely identification of such mutations is essential for offering appropriate treatment, treatment centers should offer both immunohistochemical and sequencing methods for detection of these mutations to guide treatment. Additional studies of these tumors at recurrence would also allow identification of breakthrough resistance mechanisms that may also be targetable for treatment. Due to the relative rarity of these tumors, multicenter collaborative studies will be essential in achieving long term control of these tumors.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Biomarcadores Tumorais / Proteínas Proto-Oncogênicas B-raf / Inibidores de Proteínas Quinases / Terapia de Alvo Molecular / Mutação Tipo de estudo: Clinical_trials / Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Biomarcadores Tumorais / Proteínas Proto-Oncogênicas B-raf / Inibidores de Proteínas Quinases / Terapia de Alvo Molecular / Mutação Tipo de estudo: Clinical_trials / Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article