Systematic review of tumour budding and association with common mutations in patients with colorectal cancer.
Crit Rev Oncol Hematol
; 167: 103490, 2021 Nov.
Article
em En
| MEDLINE
| ID: mdl-34619332
ABSTRACT
INTRODUCTION:
Despite a well-known prognostic role in colorectal cancer, the genomic profiling of tumour budding remains to be elucidated. We aim to review the association of common mutations with tumour budding.METHODS:
A systematic review of studies relating to tumour budding and genetic mutation in CRC was performed. The relationship between mutational status and tumour budding was evaluated using meta-analysis.RESULTS:
A total of 6153 patients from 17 articles were included. According to the meta-analysis, high-grade tumour budding was significantly associated with KRAS mutation (OR = 1.52, 95 %CI 1.13-2.02, P = 0.005) and MSS/pMMR (OR = 2.06, 95 %CI 1.42-2.97, P = 0.0001).CONCLUSION:
The significant association between high-grade tumour budding and mutated KRAS or MSS/pMMR may suggest a role of these mutations in the development of the tumour budding phenotype and be useful for stratifying patient outcome in CRC.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
/
Proteínas Proto-Oncogênicas B-raf
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article