Structural insights into the enhanced thermostability of cysteine substitution mutants of L-histidine decarboxylase from Photobacterium phosphoreum.
J Biochem
; 171(1): 31-40, 2022 Jan 07.
Article
em En
| MEDLINE
| ID: mdl-34622278
Palavras-chave
Abbreviations: AADCs, amino acid decarboxylase; ASA, accessible surface area; CL, catalytic loop; HDC, L-histidine decarboxylase; HDH, histamine dehydrogenase; HsHDC, HDC from humans; LL, long loop; 1-methoxy PMS, 1-methoxy-5-methylphenazinium methylsulfate; MjTDC, tyrosine decarboxylase from Methanocaldococcus jannaschii; MR, molecular replacement; PLP, pyridoxal 5'-phosphate; PpHDC, L-histidine decarboxylase from Photobacterium phosphoreum; PpHDC-SM, PpHDC C57S mutant; PpHDC-TM, PpHDC C57S/C101V/C282V mutant; (WST)-8, water-soluble tetrazolium salt; WT, wild-type; crystal structure; histidine decarboxylase; protein engineering; thermostability; thermostable mutant
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1
Base de dados:
MEDLINE
Assunto principal:
Cisteína
/
Histidina Descarboxilase
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article