Macrophage nuclear factor erythroid 2-related factor 2 deficiency promotes innate immune activation by tissue inhibitor of metalloproteinase 3-mediated RhoA/ROCK pathway in the ischemic liver.

Rao, Jianhua; Qiu, Jiannan; Ni, Ming; Wang, Hao; Wang, Peng; Zhang, Lei; Wang, Zeng; Liu, Mu; Cheng, Feng; Wang, Xuehao; Lu, Ling

Rao, Jianhua; Qiu, Jiannan; Ni, Ming; Wang, Hao; Wang, Peng; Zhang, Lei; Wang, Zeng; Liu, Mu; Cheng, Feng; Wang, Xuehao; Lu, Ling.

Afiliação

Rao J; Research Unit of Liver Transplantation and Transplant Immunology, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, Hepatobiliary Center of The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Qiu J; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Personalized Cancer Medicine, Nanjing Medical University, Nanjing, China.
Ni M; State Key Laboratory of Reproductive Medicine, Nanjing, China.
Wang H; Research Unit of Liver Transplantation and Transplant Immunology, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, Hepatobiliary Center of The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Wang P; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Personalized Cancer Medicine, Nanjing Medical University, Nanjing, China.
Zhang L; Research Unit of Liver Transplantation and Transplant Immunology, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, Hepatobiliary Center of The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Wang Z; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Personalized Cancer Medicine, Nanjing Medical University, Nanjing, China.
Liu M; Research Unit of Liver Transplantation and Transplant Immunology, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, Hepatobiliary Center of The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Cheng F; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Personalized Cancer Medicine, Nanjing Medical University, Nanjing, China.
Wang X; Research Unit of Liver Transplantation and Transplant Immunology, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, Hepatobiliary Center of The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Lu L; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Personalized Cancer Medicine, Nanjing Medical University, Nanjing, China.

Hepatology ; 75(6): 1429-1445, 2022 06.

Article em En | MEDLINE | ID: mdl-34624146

Assuntos

Imunidade Inata; Fígado; Fator 2 Relacionado a NF-E2; Traumatismo por Reperfusão; Animais; Humanos; Inflamação/metabolismo; Isquemia/complicações; Isquemia/metabolismo; Isquemia/patologia; Fígado/patologia; Macrófagos/metabolismo; Metaloproteases/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Fator 2 Relacionado a NF-E2/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Traumatismo por Reperfusão/imunologia; Transdução de Sinais; Inibidor Tecidual de Metaloproteinase-3/metabolismo; Quinases Associadas a rho; Proteína rhoA de Ligação ao GTP/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão / Fator 2 Relacionado a NF-E2 / Imunidade Inata / Fígado Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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