Hydrophobic ion-pairing assembled liposomal Rhein with efficient loading for acute pancreatitis treatment.
J Microencapsul
; 38(7-8): 559-571, 2021.
Article
em En
| MEDLINE
| ID: mdl-34637365
ABSTRACT
AIM:
The present study aimed to develop liposomal Rhein by employing a hydrophobic ion-pairing technique (HIP) for improved pancreatitis therapy.METHODS:
F127 modified liposomal Rhein (F127-RPC-Lip) was prepared using a two-step process consisting of complexation first, followed by a film-ultrasonic dispersion step. The drug-phospholipid interaction was characterised by FT-IR and P-XRD. Particle size and morphology were investigated using DLS and TEM, respectively. Biodistribution and therapeutic efficacy of F127-RPC-Lip were evaluated in a rat model of acute pancreatitis.RESULTS:
F127-RPC-Lip achieved efficient drug encapsulation after complexation with lipids through non-covalent interactions and had an average hydrodynamic diameter of about 141 nm. F127-RPC-Lip demonstrated slower drug release (55.90 ± 3.60%, w/w) than Rhein solution (90.27 ± 5.11%) within 24 h. Compared with Rhein, F127-RPC-Lip exhibited prolonged systemic circulation time, superior drug distribution, and attenuated injury in the pancreas of rats post-injection.CONCLUSIONS:
HIP-assembled liposomes are a promising strategy for Rhein in treating pancreatitis.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pancreatite
/
Lipossomos
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article