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Defluorination Capability of l-2-Haloacid Dehalogenases in the HAD-Like Hydrolase Superfamily Correlates with Active Site Compactness.
Chan, Peter W Y; Chakrabarti, Nilmadhab; Ing, Chris; Halgas, Ondrej; To, Terence K W; Wälti, Marielle; Petit, Alain-Pierre; Tran, Christopher; Savchenko, Alexei; Yakunin, Alexander F; Edwards, Elizabeth A; Pomès, Régis; Pai, Emil F.
Afiliação
  • Chan PWY; Department of Biochemistry, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.
  • Chakrabarti N; Present address: Zymeworks, Inc., 1385 West 8th Avenue Suite 540, Vancouver, British Columbia, V6H 3 V9, Canada.
  • Ing C; Princess Margaret Cancer Centre, The Campbell Family Cancer Research Institute, University Health Network, Toronto, Ontario, M5G 1L7, Canada.
  • Halgas O; Molecular Medicine, Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada.
  • To TKW; Department of Biochemistry, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.
  • Wälti M; Molecular Medicine, Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada.
  • Petit AP; Present address: ProteinQure, Inc., 119 Spadina Avenue suite 304, Toronto, Ontario, M5V 2L1, Canada.
  • Tran C; Department of Biochemistry, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.
  • Savchenko A; Princess Margaret Cancer Centre, The Campbell Family Cancer Research Institute, University Health Network, Toronto, Ontario, M5G 1L7, Canada.
  • Yakunin AF; Present address: International Point of Care, Inc., 135 The West Mall, Unit 9, Toronto, Ontario, M9C 1C2, Canada.
  • Edwards EA; Princess Margaret Cancer Centre, The Campbell Family Cancer Research Institute, University Health Network, Toronto, Ontario, M5G 1L7, Canada.
  • Pomès R; Present address: Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0510, USA.
  • Pai EF; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, M5S 3E5, Canada.
Chembiochem ; 23(1): e202100414, 2022 01 05.
Article em En | MEDLINE | ID: mdl-34643018
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hidrolases Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hidrolases Idioma: En Ano de publicação: 2022 Tipo de documento: Article