The efficacy and safety of intermittent preventive treatment with sulphadoxine-pyrimethamine vs artemisinin-based drugs for malaria: a systematic review and meta-analysis.
Trans R Soc Trop Med Hyg
; 116(4): 298-309, 2022 04 04.
Article
em En
| MEDLINE
| ID: mdl-34651193
BACKGROUND: Malaria is one of the most serious global problems. The objective of this study is to assess whether intermittent preventive treatment (IPT) using artemisinin-based combination therapies (ACTs) was a promising alternative to IPT with sulphadoxine-pyrimethamine (IPT-SP). METHODS: We searched the following sources up to 12 August 2020: PubMed, The Cochrane Library, Embase, Web of Science, CNKI, CBM, VIP and WanFang Database from inception. The randomized controlled trials comparing SP with ACTs for malaria were included. Data were pooled using Stata.14 software. We performed subgroup analysis based on the different types of ACTs groups and participants. RESULTS: A total of 13 studies comprising 5180 people were included. The meta-analysis showed that ACTs had the lower risk of number of any parasitemia (RR=0.46; 95% CI 0.22 to 0.96, p=0.039; I2=90.50%, p<0.001), early treatment failure (RR=0.17; 95% CI 0.06 to 0.48, p<0.001; I2=66.60%, p=0.011) and late treatment failure (RR=0.34; 95% CI 0.13 to 0.92, p<0.001; I2=87.80%, p<0.001) compared with SP. There was no significant difference in adequate clinical response, average hemoglobin and adverse neonatal outcomes. CONCLUSION: Combinations with ACTs appear promising as suitable alternatives for IPT-SP.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Malária Falciparum
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Artemisininas
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Malária
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Antimaláricos
Tipo de estudo:
Clinical_trials
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Systematic_reviews
Limite:
Humans
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Newborn
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article