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N-methyl-d-aspartate receptor antagonism modulates P300 event-related potentials and associated activity in salience and central executive networks.
de la Salle, Sara; Shah, Dhrasti; Choueiry, Joelle; Bowers, Hayley; McIntosh, Judy; Carroll, Brooke; Ilivitsky, Vadim; Knott, Verner.
Afiliação
  • de la Salle S; School of Psychology, University of Ottawa, Ottawa, ON, Canada.
  • Shah D; School of Psychology, University of Ottawa, Ottawa, ON, Canada.
  • Choueiry J; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
  • Bowers H; Department of Psychology, University of Guelph, Guelph, ON, Canada.
  • McIntosh J; The Royal's Institute of Mental Health Research, Ottawa, ON, Canada.
  • Carroll B; The Royal's Institute of Mental Health Research, Ottawa, ON, Canada.
  • Ilivitsky V; Department of Psychiatry, University of Ottawa and the Royal Ottawa Mental Health Centre, Ottawa, ON, Canada.
  • Knott V; School of Psychology, University of Ottawa, Ottawa, ON, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada; The Royal's Institute of Mental Health Research, Ottawa, ON, Canada; Department of Psychiatry, University of Ottawa and the Royal Ottawa Mental Hea
Pharmacol Biochem Behav ; 211: 173287, 2021 12.
Article em En | MEDLINE | ID: mdl-34653398
ABSTRACT
Impairments in auditory information processing in schizophrenia as indexed electrophysiologically by P300 deficits during novelty (P3a) and target (P3b) processing are linked to N -methyl- D -aspartate receptor (NMDAR) dysfunction. This study in 14 healthy volunteers examined the effects of a subanesthetic dose of the NMDAR antagonist ketamine on P300 and their relationship to psychomimetic symptoms and cortical source activity (with eLORETA). Ketamine reduced early (e- P3a) and late (l-P3a) novelty P300 at sensor (scalp)-level and at source-level in the salience network. Increases in dissociation symptoms were negatively correlated with ketamine-induced P3b changes, at sensor-level and source-level, in both salience and central executive networks. These P3a alterations during novelty processing, and the symptom-related P3b changes during target processing support a model of NMDAR hypofunction underlying disrupted auditory attention in schizophrenia.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esquizofrenia / Receptores de N-Metil-D-Aspartato / Potenciais Evocados P300 / Ketamina Tipo de estudo: Clinical_trials / Risk_factors_studies Limite: Adult / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esquizofrenia / Receptores de N-Metil-D-Aspartato / Potenciais Evocados P300 / Ketamina Tipo de estudo: Clinical_trials / Risk_factors_studies Limite: Adult / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article