Site selective synthesis and anti-inflammatory evaluation of Spiro-isoxazoline stitched adducts of arteannuin B.

Ur Rasool, Javeed; Sawhney, Gifty; Shaikh, Majeed; Nalli, Yedukondalu; Madishetti, Sreedhar; Ahmed, Zabeer; Ali, Asif

Ur Rasool, Javeed; Sawhney, Gifty; Shaikh, Majeed; Nalli, Yedukondalu; Madishetti, Sreedhar; Ahmed, Zabeer; Ali, Asif.

Afiliação

Ur Rasool J; Natural Product and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific & Innovative Research (AcSIR), Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110001, India.
Sawhney G; Academy of Scientific & Innovative Research (AcSIR), Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110001, India; Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, J&K 180001, India.
Shaikh M; Natural Product and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India.
Nalli Y; Natural Product and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India.
Madishetti S; Academy of Scientific & Innovative Research (AcSIR), Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110001, India; Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, J&K 180001, India.
Ahmed Z; Academy of Scientific & Innovative Research (AcSIR), Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110001, India; Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, J&K 180001, India.
Ali A; Natural Product and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific & Innovative Research (AcSIR), Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110001, India; CSIR-Institute of Genomics and Integrative Biology, Mall

Bioorg Chem ; 117: 105408, 2021 12.

Article em En | MEDLINE | ID: mdl-34655840

Assuntos

Anti-Inflamatórios/química; Anti-Inflamatórios/farmacologia; Artemisininas/química; Artemisininas/farmacologia; Animais; Anti-Inflamatórios/síntese química; Artemisininas/síntese química; Citocinas/antagonistas & inibidores; Citocinas/metabolismo; Isoxazóis/síntese química; Isoxazóis/química; Isoxazóis/farmacologia; Camundongos; Óxido Nítrico/antagonistas & inibidores; Óxido Nítrico/metabolismo; Células RAW 264.7

Palavras-chave

Anti-inflammatory activity; Arteannuin B; Artemisia annua; Cytotoxicity; Spiro-isoxazoline

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artemisininas / Anti-Inflamatórios Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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