Genetically identified amygdala-striatal circuits for valence-specific behaviors.
Nat Neurosci
; 24(11): 1586-1600, 2021 11.
Article
em En
| MEDLINE
| ID: mdl-34663958
ABSTRACT
The basolateral amygdala (BLA) plays essential roles in behaviors motivated by stimuli with either positive or negative valence, but how it processes motivationally opposing information and participates in establishing valence-specific behaviors remains unclear. Here, by targeting Fezf2-expressing neurons in the BLA, we identify and characterize two functionally distinct classes in behaving mice, the negative-valence neurons and positive-valence neurons, which innately represent aversive and rewarding stimuli, respectively, and through learning acquire predictive responses that are essential for punishment avoidance or reward seeking. Notably, these two classes of neurons receive inputs from separate sets of sensory and limbic areas, and convey punishment and reward information through projections to the nucleus accumbens and olfactory tubercle, respectively, to drive negative and positive reinforcement. Thus, valence-specific BLA neurons are wired with distinctive input-output structures, forming a circuit framework that supports the roles of the BLA in encoding, learning and executing valence-specific motivated behaviors.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Atenção
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Aprendizagem da Esquiva
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Corpo Estriado
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Proteínas de Ligação a DNA
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Tonsila do Cerebelo
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Rede Nervosa
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Proteínas do Tecido Nervoso
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article