Atypical Renal Clearance of Nanoparticles Larger Than the Kidney Filtration Threshold.
Int J Mol Sci
; 22(20)2021 Oct 17.
Article
em En
| MEDLINE
| ID: mdl-34681853
ABSTRACT
In recent years, several publications reported that nanoparticles larger than the kidney filtration threshold were found intact in the urine after being injected into laboratory mice. This theoretically should not be possible, as it is widely known that the kidneys prevent molecules larger than 6-8 nm from escaping into the urine. This is interesting because it implies that some nanoparticles can overcome the size limit for renal clearance. What kinds of nanoparticles can "bypass" the glomerular filtration barrier and cross into the urine? What physical and chemical characteristics are essential for nanoparticles to have this ability? And what are the biomolecular and cellular mechanisms that are involved? This review attempts to answer those questions and summarize known reports of renal-clearable large nanoparticles.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Nanopartículas
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Barreira de Filtração Glomerular
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Rim
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article