High Mobility Group Box 1 Protein in Cerebral Thromboemboli.
Int J Mol Sci
; 22(20)2021 Oct 19.
Article
em En
| MEDLINE
| ID: mdl-34681935
ABSTRACT
High-mobility group box 1 protein (HMGB1) is a damage-associated molecular pattern (DAMP) involved in neutrophil extracellular trap (NET) formation and thrombosis. NETs are regularly found in cerebral thromboemboli. We here analyzed associated HMGB1 expression in human thromboemboli retrieved via mechanical thrombectomy from 37 stroke patients with large vessel occlusion. HMGB1 was detected in all thromboemboli, accounting for 1.7% (IQR 0.6-6.2%) of the total thromboemboli area and was found to be colocalized with neutrophils and NETs and in spatial proximity to platelets. Correlation analysis revealed that the detection of HMGB1 was strongly related to the number of neutrophils (r = 0.58, p = 0.0002) and platelets (r = 0.51, p = 0.001). Our results demonstrate that HMGB1 is a substantial constituent of thromboemboli causing large vessel occlusion stroke.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Tromboembolia
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Plaquetas
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Isquemia Encefálica
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Trombose Intracraniana
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Proteína HMGB1
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Neutrófilos
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article