Prenatal dexamethasone exposure programs the decreased testosterone synthesis in offspring rats by low level of endogenous glucocorticoids.

Liu, Min; Liu, Yi; Pei, Lin-Guo; Zhang, Qi; Xiao, Hao; Chen, Ya-Wen; Wang, Hui

Liu, Min; Liu, Yi; Pei, Lin-Guo; Zhang, Qi; Xiao, Hao; Chen, Ya-Wen; Wang, Hui.

Afiliação

Liu M; Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan, 430071, China.
Liu Y; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, 430071, China.
Pei LG; Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan, 430071, China.
Zhang Q; Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan, 430071, China.
Xiao H; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, 430071, China.
Chen YW; Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan, 430071, China.
Wang H; Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan, 430071, China.

Acta Pharmacol Sin ; 43(6): 1461-1472, 2022 Jun.

Article em En | MEDLINE | ID: mdl-34697420

Assuntos

MicroRNAs; Efeitos Tardios da Exposição Pré-Natal; Animais; Corticosterona; Dexametasona/farmacologia; Feminino; Glucocorticoides; Histona Desacetilases; Humanos; Masculino; Gravidez; Ratos; Ratos Wistar; Testosterona

Palavras-chave

Leydig cells (TM3); dexamethasone; endogenous glucocorticoids; epigenetic modification; insulin-like growth factor 1; prenatal exposure; steroidogenic acute regulatory protein; testis; testosterone synthesis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / MicroRNAs Limite: Animals / Female / Humans / Male / Pregnancy Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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