Development of prognostic nomograms using institutional data for patients with triple-negative breast cancer.
Future Oncol
; 17(36): 5077-5091, 2021 Dec.
Article
em En
| MEDLINE
| ID: mdl-34704816
ABSTRACT
Background:
Triple-negative breast cancer (TNBC) is an aggressive disease. Nomograms can predict prognosis of patients with TNBC.Methods:
A total of 745 eligible TNBC patients were recruited and randomly divided into training and validation groups. Endpoints were disease-free survival and overall survival. Concordance index, area under the curve and calibration curves were used to analyze the predictive accuracy and discriminative ability of nomograms.Results:
Based on the training cohort, neutrophil-to-lymphocyte ratio, positive lymph nodes, tumor size and tumor-infiltrating lymphocytes were used to construct a nomogram for disease-free survival. In addition, age was added to the overall survival nomogram.Conclusion:
The current study developed and validated well-calibrated nomograms for predicting disease-free survival and overall survival in patients with TNBC.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Nomogramas
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Neoplasias de Mama Triplo Negativas
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Middle aged
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article