MiR-3188 regulates the proliferation and apoptosis of hepatocellular carcinoma cells by targeting CXCL14.
Biomark Med
; 15(17): 1611-1621, 2021 12.
Article
em En
| MEDLINE
| ID: mdl-34704819
ABSTRACT
Aim:
The study aimed to probe into the functions and mechanisms of miR-3188 in hepatocellular carcinoma (HCC). Materials &methods:
Quantitative real-time PCR and western blot were implemented to detect the expressions of miR-3188 and CXCL14 in HCC tissues and cell lines. CCK-8, 5-ethynyl-2'-deoxyuridine and flow cytometry assays were performed to assess cell viability, proliferation and apoptosis. A dual-luciferase reporter assay was conducted to investigate the relationship between miR-3188 and CXCL14.Results:
miR-3188 is up-regulated in HCC tissues. MiR-3188 overexpression promoted cell viability and proliferation but inhibited the apoptosis of HCC cells. CXCL14 was proven to be a target of miR-3188, and CXCL14 reversed the effects of miR-3188 on HCC cells.Conclusion:
MiR-3188 regulates the growth and apoptosis of HCC cells by targeting CXCL14.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Apoptose
/
Carcinoma Hepatocelular
/
Quimiocinas CXC
/
MicroRNAs
/
Neoplasias Hepáticas
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article