Immortalization in culture: occurrence at a late stage in the progression of breast cancer.
J Natl Cancer Inst
; 78(4): 611-5, 1987 Apr.
Article
em En
| MEDLINE
| ID: mdl-3470538
ABSTRACT
The properties in culture of 3 breast cancer effusion metastases, obtained over approximately 2 years from the same patient, were examined. Despite repeated attempts with cryopreserved cells, only the last specimen reproducibly exhibited immortality in culture; the first 2 specimens grew initially but failed to develop into cell lines. Each specimen was unique in morphology and growth properties, although karyotypic markers indicated a common origin. Aberrations of chromosomes 1 and 11 marked these near-diploid cells, and further structural alterations of chromosome 11 accompanied the transition of biological properties observed in the third specimen.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Linhagem Celular
Limite:
Adult
/
Animals
/
Female
/
Humans
Idioma:
En
Ano de publicação:
1987
Tipo de documento:
Article