Synthesis of Dibenzotropones by Alkyne-Carbonyl Metathesis.
J Org Chem
; 86(21): 14420-14432, 2021 11 05.
Article
em En
| MEDLINE
| ID: mdl-34708654
ABSTRACT
Dibenzocycloheptanones (dibenzotropones) were prepared by Brønsted acid mediated intramolecular alkyne-carbonyl metathesis (ACM) reactions. The cyclization precursors are readily available by Sonogashira reaction of 2-bromobenzoyl chloride with terminal alkynes, followed by Suzuki reactions with benzaldehydes. The ACM reactions are highly modular and atom economic and allow for the construction of two regioisomeric series of dibenzotropones.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Benzaldeídos
/
Alcinos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article