Microbial community networks across body sites are associated with susceptibility to respiratory infections in infants.
Commun Biol
; 4(1): 1233, 2021 10 28.
Article
em En
| MEDLINE
| ID: mdl-34711948
ABSTRACT
Respiratory tract infections are a major cause of morbidity and mortality worldwide in young children. Concepts such as the gut-lung axis have highlighted the impact of microbial communities at distal sites in mediating disease locally. However, little is known about the extent to which microbial communities from multiple body sites are linked, and how this relates to disease susceptibility. Here, we combine 16S-based rRNA sequencing data from 112 healthy, term born infants, spanning three body sites (oral cavity, nasopharynx, gut) and the first six months of life. Using a cross-niche microbial network approach, we show that, already from the first week of life on, there is a strong association between both network structure and species essential to these structures (hub species), and consecutive susceptibility to respiratory tract infections in this cohort. Our findings underline the crucial role of cross-niche microbial connections in respiratory health.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções Respiratórias
/
Bactérias
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Nasofaringe
/
Trato Gastrointestinal
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Microbiota
/
Boca
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Humans
/
Infant
/
Newborn
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article