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Evaluation of Bacteriophage Cocktails Alone and in Combination with Daptomycin against Daptomycin-Nonsusceptible Enterococcus faecium.
Morrisette, Taylor; Lev, Katherine L; Canfield, Gregory S; Duerkop, Breck A; Kebriaei, Razieh; Stamper, Kyle C; Holger, Dana; Lehman, Susan M; Willcox, Smaranda; Arias, Cesar A; Rybak, Michael J.
Afiliação
  • Morrisette T; Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA.
  • Lev KL; Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA.
  • Canfield GS; Department of Infectious Diseases, University of Colorado School of Medicine, Aurora, Colorado, USA.
  • Duerkop BA; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
  • Kebriaei R; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
  • Stamper KC; Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA.
  • Holger D; Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA.
  • Lehman SM; Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA.
  • Willcox S; Center for Biologics Evaluation and Research, United States Food and Drug Administrationgrid.417587.8, Silver Spring, Maryland, USA.
  • Arias CA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Rybak MJ; Division of Infectious Diseases, Houston Methodist Hospital, Houston, Texas, USA.
Antimicrob Agents Chemother ; 66(1): e0162321, 2022 01 18.
Article em En | MEDLINE | ID: mdl-34723631
ABSTRACT
Enterococcus faecium is a significant multidrug-resistant pathogen. Bacteriophage cocktails are being proposed to complement antibiotic therapy. After a screen of 8 E. faecium strains against 4 phages, 2 phages (113 and 9184) with the broadest host ranges were chosen for further experiments. Transmission electron microscopy, whole-genome sequencing, comparative genome analyses, and time-kill analyses were performed. Daptomycin (DAP) plus the phage cocktail (113 [myophage] and 9184 [siphopage]) showed bactericidal activity in most regimens, while DAP addition prevented phage 9184 resistance against daptomycin-nonsusceptible E. faecium.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bacteriófagos / Enterococcus faecium / Daptomicina Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bacteriófagos / Enterococcus faecium / Daptomicina Idioma: En Ano de publicação: 2022 Tipo de documento: Article