Differences in human IgG1 and IgG4 S228P monoclonal antibodies viscosity and self-interactions: Experimental assessment and computational predictions of domain interactions.

Lai, Pin-Kuang; Ghag, Gaurav; Yu, Yao; Juan, Veronica; Fayadat-Dilman, Laurence; Trout, Bernhardt L

Lai, Pin-Kuang; Ghag, Gaurav; Yu, Yao; Juan, Veronica; Fayadat-Dilman, Laurence; Trout, Bernhardt L.

Afiliação

Lai PK; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts USA.
Ghag G; Current Address: Department of Chemical Engineering and Materials Science, Stevens Institute of Technology, Hoboken, New Jersey USA.
Yu Y; Merck & Co, Discovery Biologics, Protein Sciences Department, South San Francisco, CA , USA.
Juan V; Merck & Co, Discovery Biologics, Protein Sciences Department, South San Francisco, CA , USA.
Fayadat-Dilman L; Merck & Co, Discovery Biologics, Protein Sciences Department, South San Francisco, CA , USA.
Trout BL; Merck & Co, Discovery Biologics, Protein Sciences Department, South San Francisco, CA , USA.

MAbs ; 13(1): 1991256, 2021.

Article em En | MEDLINE | ID: mdl-34747330

Assuntos

Anticorpos Monoclonais; Imunoglobulina G; Anticorpos Monoclonais/química; Anticorpos Monoclonais Humanizados; Regiões Determinantes de Complementaridade/química; Humanos; Imunoglobulina G/química; Viscosidade

Palavras-chave

IgG1; IgG4 S228P; IgG4P; Monoclonal antibody self-interaction; computational models; developability; diffusion interaction parameter; monoclonal antibody viscosity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imunoglobulina G / Anticorpos Monoclonais Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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