A novel thiol-labile cysteine protecting group for peptide synthesis based on a pyridazinedione (PD) scaffold.
Chem Commun (Camb)
; 58(5): 645-648, 2022 Jan 13.
Article
em En
| MEDLINE
| ID: mdl-34747956
ABSTRACT
Herein we report a thiol-labile cysteine protecting group based on an unsaturated pyridazinedione (PD) scaffold. We establish compatibility of the PD in conventional solid phase peptide synthesis (SPPS), showcasing this in the on-resin synthesis of biologically relevant oxytocin. Furthermore, we establish the applicability of the PD protecting group towards both microwave-assisted SPPS and native chemical ligation (NCL) in a model system.
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Base de dados:
MEDLINE
Assunto principal:
Técnicas de Síntese em Fase Sólida
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article