[Pharmacokinetic interactions of fruit juices and herbal preparations]. / Jugos de fruta y productos herbáceos como perpetradores de interacciones farmacocinéticas mediadas por enzimas metabolizadoras y transportadores de membrana. Relevancia en clínica.
Rev Med Chil
; 149(7): 1036-1046, 2021 Jul.
Article
em Es
| MEDLINE
| ID: mdl-34751306
ABSTRACT
Drug disposition in the human body is strongly influenced by transporters and metabolizing enzymes expressed in key organs including intestine, liver and kidney. Since drugs and chemicals present in foods such as fruit juices and herb-based products are substrates of the above-mentioned proteins, there is a high probability of pharmacokinetic interactions. Findings from preclinical and clinical studies helped to characterize the mechanisms by which the components of fruit juices and herbs act as perpetrators of pharmacokinetic interactions. The aim of this review is to provide an overview of pharmacokinetic fruit juice- and herb-drug interactions that could be relevant in the clinical setting.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Preparações de Plantas
/
Sucos de Frutas e Vegetais
Limite:
Humans
Idioma:
Es
Ano de publicação:
2021
Tipo de documento:
Article