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Design and modeling of a Laue lens for radiation therapy with hard x-ray photons.
Girou, David; Ford, Eric; Wade, Colin; van Aarle, Casper; Uliyanov, Alexei; Hanlon, Lorraine; Tomsick, John A; Zoglauer, Andreas; Collon, Maximilien J; Beijersbergen, Marco W; Barrière, Nicolas M.
Afiliação
  • Girou D; cosine measurement systems, Oosteinde 36, 2361 HE Warmond, The Netherlands.
  • Ford E; Huygens-Kamerlingh Onnes Laboratory, Leiden University, Postbus 9504, 2300 RA Leiden, The Netherlands.
  • Wade C; Department of Radiation Oncology, University of Washington, Seattle, WA 98195, United States of America.
  • van Aarle C; cosine measurement systems, Oosteinde 36, 2361 HE Warmond, The Netherlands.
  • Uliyanov A; School of Physics and Centre for Space Research, University College Dublin, Belfield, Dublin 4, Ireland.
  • Hanlon L; cosine measurement systems, Oosteinde 36, 2361 HE Warmond, The Netherlands.
  • Tomsick JA; Delft University of Technology, Faculty of Applied Sciences, Department of Radiation Science and Technology, Mekelweg 15, 2629 JB Delft, The Netherlands.
  • Zoglauer A; School of Physics and Centre for Space Research, University College Dublin, Belfield, Dublin 4, Ireland.
  • Collon MJ; School of Physics and Centre for Space Research, University College Dublin, Belfield, Dublin 4, Ireland.
  • Beijersbergen MW; Space Sciences Laboratory, University of California, Berkeley, 7 Gauss Way, Berkeley, CA 94720, United States of America.
  • Barrière NM; Space Sciences Laboratory, University of California, Berkeley, 7 Gauss Way, Berkeley, CA 94720, United States of America.
Phys Med Biol ; 66(24)2021 12 07.
Article em En | MEDLINE | ID: mdl-34757951
ABSTRACT
We have designed and modeled a novel optical system composed of a Laue lens coupled to an x-ray tube that produces a focused beam in an energy range near 100 keV (λ= 12.4 picometer). One application of this system is radiation therapy where it could enable treatment units that are considerably simpler and lower in cost than present technologies relying on linear accelerators. The Laue lens is made of Silicon Laue components which exploit the silicon pore optics technology. The lens concentrates photons to a small region thus allowing high dose rates at the focal area with very much lower dose rates at the skin and superficial regions. Monte Carlo simulations with Geant4 indicate a dose deposition rate of 0.2 Gy min-1in a cylindrical volume of 0.7 mm diameter and 10 mm length, and a dose ratio of 72 at the surface (skin) compared to the focus placed 10 cm within a water phantom. Work is ongoing to newer generation crystal technologies to increase dose rate.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Silício / Fótons Tipo de estudo: Health_economic_evaluation Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Silício / Fótons Tipo de estudo: Health_economic_evaluation Idioma: En Ano de publicação: 2021 Tipo de documento: Article