PMP2/FABP8 induces PI(4,5)P<sub>2</sub>-dependent transbilayer reorganization of sphingomyelin in the plasma membrane.

Abe, Mitsuhiro; Makino, Asami; Murate, Motohide; Hullin-Matsuda, Françoise; Yanagawa, Masataka; Sako, Yasushi; Kobayashi, Toshihide

PMP2/FABP8 induces PI(4,5)P₂-dependent transbilayer reorganization of sphingomyelin in the plasma membrane.

Abe, Mitsuhiro; Makino, Asami; Murate, Motohide; Hullin-Matsuda, Françoise; Yanagawa, Masataka; Sako, Yasushi; Kobayashi, Toshihide.

Afiliação

Abe M; Lipid Biology Laboratory, RIKEN, Wako, Saitama 351-0198, Japan; Cellular Informatics Laboratory, RIKEN, Wako, Saitama 351-0198, Japan. Electronic address: abemitsu@riken.jp.
Makino A; Lipid Biology Laboratory, RIKEN, Wako, Saitama 351-0198, Japan; Cellular Informatics Laboratory, RIKEN, Wako, Saitama 351-0198, Japan.
Murate M; Lipid Biology Laboratory, RIKEN, Wako, Saitama 351-0198, Japan; Cellular Informatics Laboratory, RIKEN, Wako, Saitama 351-0198, Japan; Laboratoire de Bioimagerie et Pathologies, UMR 7021 CNRS, Faculté de Pharmacie, Université de Strasbourg, 67401 Illkirch, France.
Hullin-Matsuda F; Lipid Biology Laboratory, RIKEN, Wako, Saitama 351-0198, Japan; Université de Lyon, CarMeN Laboratory, INSERM U1060, INRAE U1397, Université Claude Bernard Lyon 1, 69495 Pierre-Benite, France.
Yanagawa M; Cellular Informatics Laboratory, RIKEN, Wako, Saitama 351-0198, Japan.
Sako Y; Cellular Informatics Laboratory, RIKEN, Wako, Saitama 351-0198, Japan.
Kobayashi T; Lipid Biology Laboratory, RIKEN, Wako, Saitama 351-0198, Japan; Cellular Informatics Laboratory, RIKEN, Wako, Saitama 351-0198, Japan; Laboratoire de Bioimagerie et Pathologies, UMR 7021 CNRS, Faculté de Pharmacie, Université de Strasbourg, 67401 Illkirch, France. Electronic address: toshihide.kobay

Cell Rep ; 37(6): 109935, 2021 11 09.

Article em En | MEDLINE | ID: mdl-34758297

Assuntos

Membrana Celular/metabolismo; Doença de Charcot-Marie-Tooth/metabolismo; Proteína P2 de Mielina/metabolismo; Fosfatidilinositol 4,5-Difosfato/metabolismo; Esfingomielinas/metabolismo; Animais; Transporte Biológico; Membrana Celular/genética; Doença de Charcot-Marie-Tooth/genética; Cães; Células HeLa; Humanos; Células Madin Darby de Rim Canino; Mutação; Proteína P2 de Mielina/genética

Palavras-chave

Charcot-Marie-Tooth disease; fatty-acid-binding protein; flip-flop; genetic screening; immunoelectron microscopy; lipid asymmetry; lipid domain; lipid imaging; membrane tubulation; super-resolution microscopy

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esfingomielinas / Doença de Charcot-Marie-Tooth / Membrana Celular / Proteína P2 de Mielina / Fosfatidilinositol 4,5-Difosfato Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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