PDK1 Inhibitor BX795 Improves Cisplatin and Radio-Efficacy in Oral Squamous Cell Carcinoma by Downregulating the PDK1/CD47/Akt-Mediated Glycolysis Signaling Pathway.

Pai, Shin; Yadav, Vijesh Kumar; Kuo, Kuang-Tai; Pikatan, Narpati Wesa; Lin, Chun-Shu; Chien, Ming-Hsien; Lee, Wei-Hwa; Hsiao, Michael; Chiu, Shao-Chih; Yeh, Chi-Tai; Tsai, Jo-Ting

Pai, Shin; Yadav, Vijesh Kumar; Kuo, Kuang-Tai; Pikatan, Narpati Wesa; Lin, Chun-Shu; Chien, Ming-Hsien; Lee, Wei-Hwa; Hsiao, Michael; Chiu, Shao-Chih; Yeh, Chi-Tai; Tsai, Jo-Ting.

Afiliação

Pai S; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Yadav VK; Department of Oral & Maxillofacial Surgery, Saint Martin de Parres Hospital, Chiayi City 600, Taiwan.
Kuo KT; Department of Medical Research and Education, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan.
Pikatan NW; Department of Medical Laboratory Science and Biotechnology, Yuanpei University of Medical Technology, Hsinchu City 300, Taiwan.
Lin CS; Division of Thoracic Surgery, Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Chien MH; Division of Thoracic Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan.
Lee WH; Department of Medical Research and Education, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan.
Hsiao M; Department of Medical Laboratory Science and Biotechnology, Yuanpei University of Medical Technology, Hsinchu City 300, Taiwan.
Chiu SC; Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.
Yeh CT; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Tsai JT; Department of Medical Research and Education, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan.

Int J Mol Sci ; 22(21)2021 Oct 25.

Article em En | MEDLINE | ID: mdl-34768921

Assuntos

Cisplatino/farmacologia; Glicólise/efeitos dos fármacos; Neoplasias Bucais/tratamento farmacológico; Pirimidinas/farmacologia; Piruvato Desidrogenase Quinase de Transferência de Acetil/antagonistas & inibidores; Carcinoma de Células Escamosas de Cabeça e Pescoço/tratamento farmacológico; Tiofenos/farmacologia; Adulto; Idoso; Apoptose/efeitos dos fármacos; Antígeno CD47/metabolismo; Linhagem Celular Tumoral; Dano ao DNA/efeitos dos fármacos; Progressão da Doença; Transição Epitelial-Mesenquimal/efeitos dos fármacos; Feminino; Humanos; Masculino; Pessoa de Meia-Idade; Proteínas Proto-Oncogênicas c-akt/metabolismo; Piruvato Desidrogenase Quinase de Transferência de Acetil/genética; Piruvato Desidrogenase Quinase de Transferência de Acetil/metabolismo; Interferência de RNA; RNA Interferente Pequeno/genética; Tolerância a Radiação/fisiologia; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

CD47; OSCC; PDK1; cancer stem cells; chemo/radioresistance; glycolysis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Tiofenos / Neoplasias Bucais / Cisplatino / Carcinoma de Células Escamosas de Cabeça e Pescoço / Piruvato Desidrogenase Quinase de Transferência de Acetil / Glicólise Tipo de estudo: Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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