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Monoterpene Indole Alkaloids with Cav3.1 T-Type Calcium Channel Inhibitory Activity from Catharanthus roseus.
Deng, Zhen-Tao; Li, Wen-Yan; Wang, Lei; Zhou, Zhi-Ping; Wu, Xing-De; Ding, Zhong-Tao; Zhao, Qin-Shi.
Afiliação
  • Deng ZT; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
  • Li WY; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
  • Wang L; University of Chinese Academy of Sciences, Beijing 100049, China.
  • Zhou ZP; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
  • Wu XD; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
  • Ding ZT; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
  • Zhao QS; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Molecules ; 26(21)2021 Oct 28.
Article em En | MEDLINE | ID: mdl-34770935
Catharanthus roseus is a well-known traditional herbal medicine for the treatment of cancer, hypertension, scald, and sore in China. Phytochemical investigation on the twigs and leaves of this species led to the isolation of two new monoterpene indole alkaloids, catharanosines A (1) and B (2), and six known analogues (3-8). Structures of 1 and 2 were established by 1H-, 13C- and 2D-NMR, and HREIMS data. The absolute configuration of 1 was confirmed by single-crystal X-ray diffraction analysis. Compound 2 represented an unprecedented aspidosperma-type alkaloid with a 2-piperidinyl moiety at C-10. Compounds 6-8 exhibited remarkable Cav3.1 low voltage-gated calcium channel (LVGCC) inhibitory activity with IC50 values of 11.83 ± 1.02, 14.3 ± 1.20, and 14.54 ± 0.99 µM, respectively.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Bloqueadores dos Canais de Cálcio / Canais de Cálcio Tipo T / Catharanthus / Alcaloides Indólicos / Monoterpenos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Bloqueadores dos Canais de Cálcio / Canais de Cálcio Tipo T / Catharanthus / Alcaloides Indólicos / Monoterpenos Idioma: En Ano de publicação: 2021 Tipo de documento: Article