Risk Factors for Clostridioides Difficile Diarrhea In Solid Organ Transplantation Recipients.
Transplant Proc
; 53(10): 2826-2832, 2021 Dec.
Article
em En
| MEDLINE
| ID: mdl-34772488
ABSTRACT
BACKGROUND:
There is limited knowledge about risk factors for Clostridioides difficile infection (CDI) and recurrent CDI in solid organ transplant (SOT) recipients.METHODS:
A case-control study of CDI in SOT recipients compared with controls (SOT recipients who did not present CDI).RESULTS:
Sixty-seven patients from 1089 SOT recipients (6.2%) suffered at least one episode of CDI. The mean age was 55 ± 12 years and 20 cases (69%) were men. The accumulated incidence was 8% in liver transplantation, 6.2% in lung transplantation, 5.4% in heart transplantation, and 4.7% in kidney transplantation. Twenty-nine cases (43.3%) were diagnosed during the first 3 months after SOT. Forty-one cases (61.2%) were hospital acquired. Thirty-one patients with CDI presented with mild-moderate infection (46.3%), 30 patients with severe infection (44.8%), and 6 patients with severe-complicated disease (9%). Independent variables found to be related with CDI were hospitalization in the previous 3 months (odds ratio 2.99; [95% confidence interval 1.21-7.37]) and the use of quinolones in the previous month (odds ratio 3.71 [95% confidence interval 1.16-11.8]). Eleven patients (16.4%) had at least one recurrence of CDI. Previous treatment with amoxicillin-clavulanate, severe-complicated index episode, and high serum creatinine were associated with recurrent CDI in the univariant analysisCONCLUSIONS:
Liver transplant recipients presented the highest incidence of CDI among SOT recipients. Risk factors for CDI were hospitalization in the previous 3 months and the use of quinolones in the previous month.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Clostridioides difficile
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Transplante de Órgãos
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Infecções por Clostridium
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article