M&M: A maximum duration design with the Maxcombo test for a group sequential trial of an immunotherapy with a random delayed treatment effect.

Li, Bosheng; Su, Liwen; Ye, Yuqing; Yan, Fangrong

Li, Bosheng; Su, Liwen; Ye, Yuqing; Yan, Fangrong.

Afiliação

Li B; Research Center of Biostatistics and Computational Pharmacy, China Pharmaceutical University, Nanjing, China.
Su L; Research Center of Biostatistics and Computational Pharmacy, China Pharmaceutical University, Nanjing, China.
Ye Y; Research Center of Biostatistics and Computational Pharmacy, China Pharmaceutical University, Nanjing, China.
Yan F; Research Center of Biostatistics and Computational Pharmacy, China Pharmaceutical University, Nanjing, China.

Stat Med ; 41(4): 815-830, 2022 02 20.

Article em En | MEDLINE | ID: mdl-34783047

Assuntos

Neoplasias; Tempo para o Tratamento; Simulação por Computador; Humanos; Imunoterapia/métodos; Neoplasias/tratamento farmacológico; Projetos de Pesquisa; Tamanho da Amostra

Palavras-chave

Maxcombo test; Monte Carlo simulation; cancer immunotherapy; group sequential trial; maximum duration design; random delayed treatment effect

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tempo para o Tratamento / Neoplasias Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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