Chemical Composition and Biological Screening of the Essential Oils of Micromeria macrosiphon and M. arganietorum (Lamiaceae).
Chem Biodivers
; 18(12): e2100653, 2021 Dec.
Article
em En
| MEDLINE
| ID: mdl-34786843
ABSTRACT
The chemical composition and inâ
vitro biological activities of the essential oil (EO) of Micromeria macrosiphon Coss. and M.â
arganietorum (J. Emb.) R. Morales, two Lamiaceae endemic to south Morocco, were investigated. GC/MS analysis resulted in the identification of 36 metabolites from the EO of M.â
macrosiphon, 45 from M.â
arganietorum. Borneol was the major metabolite in both oils and together with related derivatives such as camphor, accounted for 2/3 of the EO of M.â
macrosiphon, 1/3 of those of M.â
arganietorum. Pinene and terpinene derivatives were also present in high proportions. From a chemotaxonomic point of view, the composition of the examined samples may be related to those of other species endemic to Macaronesia. Both EOs showed significant toxicity towards liver HepG2 and melanoma B16 4A5 tumor cell lines at 100â
µg/mL; however, they were also cytotoxic towards S17 normal cell lines, with a selectivity index <1. No antibacterial activity was noticed against 52 strains at 100â
µg/mL.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Óleos Voláteis
/
Lamiaceae
/
Antineoplásicos Fitogênicos
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article