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Biocompatible photoinduced CuAAC using sodium pyruvate.
Jeong, Jaepil; Szczepaniak, Grzegorz; Yerneni, Saigopalakrishna S; Lorandi, Francesca; Jafari, Hossein; Lathwal, Sushil; Das, Subha R; Matyjaszewski, Krzysztof.
Afiliação
  • Jeong J; Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA. gszczepa@andrew.cmu.edu.
  • Szczepaniak G; Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA. gszczepa@andrew.cmu.edu.
  • Yerneni SS; University of Warsaw, Faculty of Chemistry, Pasteura 1, 02-093 Warsaw, Poland.
  • Lorandi F; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA.
  • Jafari H; Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA. gszczepa@andrew.cmu.edu.
  • Lathwal S; Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA. gszczepa@andrew.cmu.edu.
  • Das SR; Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA. gszczepa@andrew.cmu.edu.
  • Matyjaszewski K; Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA. gszczepa@andrew.cmu.edu.
Chem Commun (Camb) ; 57(95): 12844-12847, 2021 Nov 30.
Article em En | MEDLINE | ID: mdl-34787596
Sodium pyruvate, a natural intermediate produced during cellular metabolism, is commonly used in buffer solutions and media for biochemical applications. Here we show the use of sodium pyruvate (SP) as a reducing agent in a biocompatible aqueous photoinduced azide-alkyne cycloaddition (CuAAC) reaction. This copper(I)-catalyzed 1,3-dipolar cycloaddition is triggered by SP under UV light irradiation, exhibits oxygen tolerance and temporal control, and provides a convenient alternative to current CuAAC systems, particularly for biomolecular conjugations.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piruvatos / Azidas / Materiais Biocompatíveis / Cobre / Alcinos Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piruvatos / Azidas / Materiais Biocompatíveis / Cobre / Alcinos Idioma: En Ano de publicação: 2021 Tipo de documento: Article