Precision Medicine: Towards Individualized Dosing in Pediatric Rheumatology.
Rheum Dis Clin North Am
; 48(1): 305-330, 2022 02.
Article
em En
| MEDLINE
| ID: mdl-34798954
ABSTRACT
Despite an increase in the number of available therapeutics, many children with rheumatic disease continue to experience active inflammatory disease and treatment failure. One reason for treatment failure is the lack of dosing paradigms to account for the wide between-patient variability in drug pharmacokinetics because of developmental changes or genetic polymorphisms that effect drug absorption, distribution, metabolism, and elimination. This review highlights several strategies to optimize dosing for biologic and nonbiologic disease-modifying antirheumatic drugs, including therapeutic drug monitoring, pharmacogenomics, and the use of pharmacokinetic/pharmacodynamic modeling.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Reumatologia
/
Doenças Reumáticas
/
Antirreumáticos
Tipo de estudo:
Prognostic_studies
Limite:
Child
/
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article