Glyceraldehyde-3-phosphate dehydrogenase and glutamine synthetase inhibition in the presence of pro-inflammatory cytokines contribute to the metabolic imbalance of diabetic retinopathy.

Shivashankar, Gaganashree; Lim, Julie C; Acosta, Monica L

Shivashankar, Gaganashree; Lim, Julie C; Acosta, Monica L.

Afiliação

Shivashankar G; School of Optometry and Vision Science and the New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand.
Lim JC; Department of Physiology, School of Medical and Health Sciences and the New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand.
Acosta ML; School of Optometry and Vision Science and the New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand. Electronic address: m.acosta@auckland.ac.nz.

Exp Eye Res ; 213: 108845, 2021 12.

Article em En | MEDLINE | ID: mdl-34800480

Assuntos

Retinopatia Diabética/enzimologia; Inibidores Enzimáticos/farmacologia; Glutamato-Amônia Ligase/antagonistas & inibidores; Gliceraldeído-3-Fosfato Desidrogenases/antagonistas & inibidores; Interleucina-1beta/farmacologia; Retina/efeitos dos fármacos; Fator de Necrose Tumoral alfa/farmacologia; Trifosfato de Adenosina/metabolismo; Animais; Western Blotting; Retinopatia Diabética/patologia; Feminino; Glucose/farmacologia; Hiperglicemia/metabolismo; Ácido Iodoacético/farmacologia; L-Lactato Desidrogenase/metabolismo; Metionina Sulfoximina/farmacologia; Camundongos; Camundongos Endogâmicos C57BL; Retina/enzimologia; Retina/patologia

Palavras-chave

Diabetic retinopathy; Glutamate recycling; Glutamine synthetase; Glyceraldehyde 3-phosphate dehydrogenase; Glycolysis; Inflammation; Metabolic dysregulation; Retina

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Retina / Fator de Necrose Tumoral alfa / Retinopatia Diabética / Inibidores Enzimáticos / Interleucina-1beta / Glutamato-Amônia Ligase / Gliceraldeído-3-Fosfato Desidrogenases Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google