Yeast metabolic engineering for carbon dioxide fixation and its application.
Bioresour Technol
; 346: 126349, 2022 Feb.
Article
em En
| MEDLINE
| ID: mdl-34800639
ABSTRACT
As numerous industrial bioprocesses rely on yeast fermentation, developing CO2-fixing yeast strains can be an attractive option toward sustainable industrial processes and carbon neutrality. Recent studies have shown that the expression of ribulose-1,5-bisphosphate carboxylase-oxygenase (RuBisCO) in yeasts, such as Saccharomyces cerevisiae and Kluyveromyces marxianus, enables mixotrophic CO2 fixation and production of biofuels. Also, the expression of a synthetic Calvin-Benson-Bassham (CBB) cycle including RuBisCO in Pichia pastoris enables autotrophic growth on CO2. This review highlights recent advances in metabolic engineering strategies to enable CO2 fixation in yeasts. Also, we discuss the potentials of other natural and synthetic metabolic pathways independent of RuBisCO for developing CO2-fixing yeast strains capable of producing value-added biochemicals.
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Base de dados:
MEDLINE
Assunto principal:
Dióxido de Carbono
/
Engenharia Metabólica
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article