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Direct effects of linoleic and linolenic acids on bovine uterine function using in vivo and in vitro studies.
Sakumoto, Ryosuke; Hayashi, Ken-Go; Iga, Kosuke.
Afiliação
  • Sakumoto R; Division of Animal Breeding and Reproduction Research, Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization (NARO), Ibaraki 305-0901, Japan.
  • Hayashi KG; Division of Animal Breeding and Reproduction Research, Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization (NARO), Ibaraki 305-0901, Japan.
  • Iga K; Division of Livestock and Forage Research, Tohoku Agricultural Research Center, NARO, Morioka 020-0198, Japan.
J Reprod Dev ; 68(1): 62-67, 2022 Feb 18.
Article em En | MEDLINE | ID: mdl-34803128
ABSTRACT
The aim of the present study was to evaluate the effects of continuous administration of linoleic acid or linolenic acid into the intra-uterine horn, ipsilateral to the corpus luteum, on the duration of the estrous cycle and plasma progesterone (P4) concentration. The effects of linoleic and linolenic acids on bovine uterine and luteal functions were also studied using a tissue culture system. Intra-uterine administration of linoleic or linolenic acid (5 mg/10 ml of each per day) in cows, between days 12 and 21, resulted in a prolonged estrous cycle compared to the average duration of the last one to three estrous cycles before administration in each group (P < 0.05). Moreover, plasma P4 concentration in cows treated with linoleic or linolenic acid was high between days 19 and 21 (linoleic acid), or on day 20 (linolenic acid), compared to that of the control cows (saline administration; P < 0.05 or lower). Both linoleic (500 µg/ml) and linolenic (5 and 500 µg/ml) acids stimulated prostaglandin (PG) E2 but inhibited PGF2α production by cultured endometrial tissue (P < 0.01), while P4 production by cultured luteal tissue was not affected. These findings suggest that both linoleic and linolenic acids support luteal P4 production by regulating endometrial PG production and, subsequently, prolonging the duration of the estrous cycle in cows.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácidos Linolênicos / Corpo Lúteo Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácidos Linolênicos / Corpo Lúteo Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article