Microglia contribute to the propagation of Aß into unaffected brain tissue.
Nat Neurosci
; 25(1): 20-25, 2022 01.
Article
em En
| MEDLINE
| ID: mdl-34811521
ABSTRACT
Microglia appear activated in the vicinity of amyloid beta (Aß) plaques, but whether microglia contribute to Aß propagation into unaffected brain regions remains unknown. Using transplantation of wild-type (WT) neurons, we show that Aß enters WT grafts, and that this is accompanied by microglia infiltration. Manipulation of microglia function reduced Aß deposition within grafts. Furthermore, in vivo imaging identified microglia as carriers of Aß pathology in previously unaffected tissue. Our data thus argue for a hitherto unexplored mechanism of Aß propagation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos beta-Amiloides
/
Microglia
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article