Sequential Knoevenagel [4+1] Cycloaddition-Condensation-Aza-Friedel-Crafts Intramolecular Cyclization: A 4-Center-3-Component Reaction Toward Tunable Fluorescent Indolizine Tetracycles.
J Org Chem
; 86(24): 17550-17559, 2021 12 17.
Article
em En
| MEDLINE
| ID: mdl-34818017
ABSTRACT
A two-step multicomponent reaction oxidation protocol is reported herein, which affords novel tunable fluorescent tetracyclic indolizines. The procedure involves a novel 4-center-3-component reaction, which proceeds via a sequential Knoevenagel condensation, [4+1] cycloaddition, and imine condensation to afford imino-indolizines. Products then undergo cyclization and are oxidized in situ to afford fluorescent tetracycles, which are readily tunable through modification of diversity elements.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Indolizinas
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article