Androgen Excess Increases Food Intake in a Rat Polycystic Ovary Syndrome Model by Downregulating Hypothalamus Insulin and Leptin Signaling Pathways Preceding Weight Gain.

Liu, Ying; Xu, Yu-Chen; Cui, Yu-Gui; Jiang, Shi-Wen; Diao, Fei-Yang; Liu, Jia-Yin; Ma, Xiang

Liu, Ying; Xu, Yu-Chen; Cui, Yu-Gui; Jiang, Shi-Wen; Diao, Fei-Yang; Liu, Jia-Yin; Ma, Xiang.

Afiliação

Liu Y; The State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Xu YC; Clinical Center of Reproductive Medicine, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Xuzhou, China.
Cui YG; The State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Jiang SW; The State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Diao FY; Center of Reproductive Medicine, State Key Laboratory of Reproductive Medicine, Research Institute for Reproductive Health and Genetic Diseases, The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi, China.
Liu JY; The State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Ma X; The State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing, China.

Neuroendocrinology ; 112(10): 966-981, 2022.

Article em En | MEDLINE | ID: mdl-34847556

Assuntos

Hiperandrogenismo; Síndrome do Ovário Policístico; Androgênios/metabolismo; Animais; Peso Corporal; Ingestão de Alimentos; Feminino; Humanos; Hipotálamo/metabolismo; Insulina/metabolismo; Leptina/metabolismo; Neuropeptídeo Y/metabolismo; Obesidade/induzido quimicamente; Obesidade/metabolismo; Síndrome do Ovário Policístico/induzido quimicamente; Síndrome do Ovário Policístico/metabolismo; RNA Mensageiro/metabolismo; Ratos; Transdução de Sinais; Testosterona/metabolismo; Aumento de Peso

Palavras-chave

Androgen excess; Food intake; Hypothalamus insulin sensitivity; Hypothalamus leptin sensitivity; Polycystic ovary syndrome

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome do Ovário Policístico / Hiperandrogenismo Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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