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Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses.
Alameh, Mohamad-Gabriel; Tombácz, István; Bettini, Emily; Lederer, Katlyn; Sittplangkoon, Chutamath; Wilmore, Joel R; Gaudette, Brian T; Soliman, Ousamah Y; Pine, Matthew; Hicks, Philip; Manzoni, Tomaz B; Knox, James J; Johnson, John L; Laczkó, Dorottya; Muramatsu, Hiromi; Davis, Benjamin; Meng, Wenzhao; Rosenfeld, Aaron M; Strohmeier, Shirin; Lin, Paulo J C; Mui, Barbara L; Tam, Ying K; Karikó, Katalin; Jacquet, Alain; Krammer, Florian; Bates, Paul; Cancro, Michael P; Weissman, Drew; Luning Prak, Eline T; Allman, David; Locci, Michela; Pardi, Norbert.
Afiliação
  • Alameh MG; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Tombácz I; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Bettini E; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Lederer K; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Sittplangkoon C; Center of Excellence in Vaccine Research and Development, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
  • Wilmore JR; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Gaudette BT; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Soliman OY; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Pine M; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Hicks P; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Manzoni TB; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Knox JJ; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Johnson JL; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Laczkó D; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Muramatsu H; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Davis B; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Meng W; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Rosenfeld AM; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Strohmeier S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Lin PJC; Acuitas Therapeutics, Vancouver, BC, Canada.
  • Mui BL; Acuitas Therapeutics, Vancouver, BC, Canada.
  • Tam YK; Acuitas Therapeutics, Vancouver, BC, Canada.
  • Karikó K; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA; BioNTech RNA Pharmaceuticals, Mainz, Germany.
  • Jacquet A; Center of Excellence in Vaccine Research and Development, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
  • Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Bates P; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Cancro MP; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Weissman D; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Luning Prak ET; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Allman D; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Locci M; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: michela.locci@pennmedicine.upenn.edu.
  • Pardi N; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: pnorbert@pennmedicine.upenn.edu.
Immunity ; 54(12): 2877-2892.e7, 2021 12 14.
Article em En | MEDLINE | ID: mdl-34852217
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos B / Linfócitos T Auxiliares-Indutores / Centro Germinativo / Vacinas contra COVID-19 / SARS-CoV-2 / COVID-19 / Vacinas de mRNA Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos B / Linfócitos T Auxiliares-Indutores / Centro Germinativo / Vacinas contra COVID-19 / SARS-CoV-2 / COVID-19 / Vacinas de mRNA Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article