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Impact of mean blood pressure and blood pressure variability after diagnosis of mild cognitive impairment and risk of dementia.
de Havenon, Adam; Muddasani, Varsha; Anadani, Mohammad; Prabhakaran, Shyam.
Afiliação
  • de Havenon A; University of Utah, Department of Neurology, Salt Lake City, Utah, USA.
  • Muddasani V; University of Utah, Department of Neurology, Salt Lake City, Utah, USA.
  • Anadani M; Department of Neurology, Washington University, St. Louis, Missouri, USA.
  • Prabhakaran S; Department of Neurology, University of Chicago, St Louis, Missouri, USA.
J Clin Hypertens (Greenwich) ; 23(12): 2124-2128, 2021 12.
Article em En | MEDLINE | ID: mdl-34862714
ABSTRACT
Hypertension and increased blood pressure variability (BPV) are associated with the development of dementia. However, previous studies did not focus on the risk of dementia among participants with mild cognitive impairment (MCI) and controlled blood pressure level. To address this limitation, the authors performed a post-hoc analysis of SPRINT MIND participants diagnosed with MCI (mean Montreal Cognitive Assessment score at diagnosis 16.1±3.1). The primary outcome was subsequent diagnosis of probable dementia. The exposure was mean blood pressure and BPV following MCI diagnosis until the end of follow-up or a dementia event (mean follow-up 2.6±1.2 years). The primary outcome occurred in 76/516 (14.7%) patients. The mean blood pressure was not significantly higher in participants who developed dementia. In the lowest quartile of BPV (systolic standard deviation), the rate of dementia was 8.5% (11/129), while in the highest quartile it was 21.7% (28/129). The highest quartile of systolic BPV had an adjusted hazard ratio for dementia of 2.73 (95% CI, 1.31-5.69) and for diastolic BPV it was 2.62 (95% CI, 1.26-5.47). In SPRINT MIND participants, the authors found that increased BPV after MCI diagnosis was associated with incident probable dementia during subsequent follow-up.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Demência / Disfunção Cognitiva / Hipertensão Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Demência / Disfunção Cognitiva / Hipertensão Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article