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Circular RNAs in physiology and non-immunological diseases.
Chen, Liang; Huang, Chuan; Shan, Ge.
Afiliação
  • Chen L; Department of Clinical Laboratory, First Affiliated Hospital of the USTC, Hefei National Laboratory for Physical Sciences at Microscale, Chinese Academy of Sciences (CAS) Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China (UTSC), Hefei, 230027, China.
  • Huang C; School of Life Sciences, Chongqing University, Chongqing 401331, China; Center of Plant Functional Genomics, Institute of Advanced Interdisciplinary Studies, Chongqing University, Chongqing 401331, China. Electronic address: chuanhuang@cqu.edu.cn.
  • Shan G; Department of Clinical Laboratory, First Affiliated Hospital of the USTC, Hefei National Laboratory for Physical Sciences at Microscale, Chinese Academy of Sciences (CAS) Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China (UTSC), Hefei, 230027, China; Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China. Electronic address: shange@ustc.ed
Trends Biochem Sci ; 47(3): 250-264, 2022 03.
Article em En | MEDLINE | ID: mdl-34865956
Circular RNAs (circRNAs) are covalently closed single-stranded RNAs. Four subclasses of circRNAs have been identified in animal cells, and they have unique features in their biogenesis, degradation, and transport. CircRNAs have diverse molecular functions in sponging miRNAs, regulating transcription, modulating RNA-binding proteins, and even encoding proteins. Some circRNAs are important regulators of various physiological processes to maintain homeostasis. Dysregulation of circRNAs is associated with human disorders, and individual circRNAs are crucial factors that contribute to major diseases including non-immunological diseases such as cancers, neurological disorders, cardiovascular disease, and metabolic disease. Debates on circRNAs have also been raised in recent years, and further studies would help to resolve these disputes and potentially lead to biomedical applications of circRNAs.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / MicroRNAs / RNA Circular / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / MicroRNAs / RNA Circular / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article