Diagnostic value of aquaporin-4-IgG live cell based assay in neuromyelitis optica spectrum disorders.
Mult Scler J Exp Transl Clin
; 7(4): 20552173211052656, 2021 Oct.
Article
em En
| MEDLINE
| ID: mdl-34868626
ABSTRACT
OBJECTIVE:
Determine the utility of aquaporin 4 IgG (AQP4-IgG) testing (live cell-based assay) for Neuromyelitis Optica Spectrum Disorders (NMOSD).METHODS:
We included Mayo Clinic patients (1/1/2018-12/31/2019) tested for serum AQP4-IgG by live cell-based flow-cytometric assay. Medical records were reviewed to assess if patients fulfilled 2015 NMOSD criteria.RESULTS:
Of 1371 patients tested, 41 were positive (3%) and all fulfilled NMOSD criteria with AQP4-IgG (specificity = 100%). Only 10/1330 testing negative met NMOSD criteria without AQP4-IgG (sensitivity = 80%) and seven of these 10 were MOG-IgG positive.CONCLUSIONS:
AQP4-IgG by live cell-based assay was highly specific and without false positives in a high throughput setting.
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Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article