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Diagnostic value of aquaporin-4-IgG live cell based assay in neuromyelitis optica spectrum disorders.
Redenbaugh, Vyanka; Montalvo, Mayra; Sechi, Elia; Buciuc, Marina; Fryer, James P; McKeon, Andrew; Lennon, Vanda A; Mills, John R; Weinshenker, Brian G; Wingerchuk, Dean M; Chen, John J; Tariq Bhatti, M; Lopez Chiriboga, A Sebastian; Pittock, Sean J; Flanagan, Eoin P.
Afiliação
  • Redenbaugh V; Departments of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA.
  • Montalvo M; Departments of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA.
  • Sechi E; Departments of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA.
  • Buciuc M; Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN, USA.
  • Fryer JP; Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN, USA.
  • McKeon A; Departments of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA.
  • Lennon VA; Departments of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA.
  • Mills JR; Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN, USA.
  • Weinshenker BG; Departments of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA.
  • Wingerchuk DM; Department of Neurology, Mayo Clinic College of Medicine, Scottsdale, AZ, USA.
  • Chen JJ; Departments of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA.
  • Tariq Bhatti M; Departments of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA.
  • Lopez Chiriboga AS; Department of Neurology, Mayo Clinic College of Medicine, Jacksonville, FL, USA.
  • Pittock SJ; Departments of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA.
  • Flanagan EP; Departments of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA.
Mult Scler J Exp Transl Clin ; 7(4): 20552173211052656, 2021 Oct.
Article em En | MEDLINE | ID: mdl-34868626
ABSTRACT

OBJECTIVE:

Determine the utility of aquaporin 4 IgG (AQP4-IgG) testing (live cell-based assay) for Neuromyelitis Optica Spectrum Disorders (NMOSD).

METHODS:

We included Mayo Clinic patients (1/1/2018-12/31/2019) tested for serum AQP4-IgG by live cell-based flow-cytometric assay. Medical records were reviewed to assess if patients fulfilled 2015 NMOSD criteria.

RESULTS:

Of 1371 patients tested, 41 were positive (3%) and all fulfilled NMOSD criteria with AQP4-IgG (specificity = 100%). Only 10/1330 testing negative met NMOSD criteria without AQP4-IgG (sensitivity = 80%) and seven of these 10 were MOG-IgG positive.

CONCLUSIONS:

AQP4-IgG by live cell-based assay was highly specific and without false positives in a high throughput setting.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article